製品の概要

  • 製品名Anti-GFAP antibody [SB61b] (HRP)
    GFAP 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [SB61b] to GFAP (HRP)
  • 標識HRP
  • 特異性ab46812 reacts with human GFAP.
  • アプリケーション適用あり: WB, IHC (Methanol fixed)more details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant GFAP (Human)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab46812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC (Methanol fixed)
  • 追加情報Immunohistochemistry (Methanol fixed cells): Use at an assay dependent dilution.
    WB: 1/2000 - 1/4000. Predicted molecular weight: 50 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
    • 組織特異性Expressed in cells lacking fibronectin.
    • 関連疾患Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
    • 配列類似性Belongs to the intermediate filament family.
    • 翻訳後修飾Phosphorylated by PKN1.
    • 細胞内局在Cytoplasm. Associated with intermediate filaments.
    • Information by UniProt
    • 参照データベース
    • 別名
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      see all

    Anti-GFAP antibody [SB61b] (HRP) (ab46812) 使用論文

    ab46812 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab46812.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"