製品の概要

  • 製品名Anti-GFAP antibody [MIG-G2], prediluted
    GFAP 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MIG-G2] to GFAP, prediluted
  • 特異性GFAP, no cross-reactivity with other filament proteins.
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Rat, Guinea pig, Human
  • 免疫原

    Purified Glial Fibrillary Acidic Protein.

  • ポジティブ・コントロール
    • Glioma, Astrocytoma.
  • 特記事項


    ab51838 is helpful in differentiation of central nervous tumours. The antibody will specifically label glioblastoma, astrocytoma and medulloblastoma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab51838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.

60 min at RT. No protease pre-treatment. Blocking of endogenous enzymes is recommended, depending on kind of secondary reagents The volume is sufficient for at least 50 immunohistochemical tests (100 µl working solution / test).

ターゲット情報

  • 機能GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
  • 組織特異性Expressed in cells lacking fibronectin.
  • 関連疾患Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
  • 配列類似性Belongs to the intermediate filament family.
  • 翻訳後修飾Phosphorylated by PKN1.
  • 細胞内局在Cytoplasm. Associated with intermediate filaments.
  • Information by UniProt
  • 参照データベース
  • 別名
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    • FLJ42474 antibody
    • FLJ45472 antibody
    • GFAP antibody
    • GFAP_HUMAN antibody
    • gfapl antibody
    • Glial fibrillary acidic protein antibody
    • Intermediate filament protein antibody
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    • xx:af506734 antibody
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    see all

Anti-GFAP antibody [MIG-G2], prediluted (ab51838) 使用論文

This product has been referenced in:
  • Shields DC  et al. Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis. Proc Natl Acad Sci U S A 95:5768-72 (1998). Read more (PubMed: 9576959) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"