製品の概要

  • 製品名
  • 製品の詳細
    Sheep polyclonal to GFAP
  • アプリケーション
    適用あり: WB, ELISA, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Rat, Human
    交差が予測される動物種: Mouse, Cow, Cynomolgus monkey
  • 免疫原

    Synthetic peptide:

    H-CKLADVYQAELRELRLRLDQ-OH

    conjugated to KLH, corresponding to amino acids in GFAP. This sequence is conseverd in Human Mouse and Rat.

  • ポジティブ・コントロール
    • IHC-P and ICC/IF: Human and Rat brain tissue WB: Human brain homogenate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab90601 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
IHC-P
ICC/IF
  • 追加情報
    ELISA: 1/100 - 1/10000.
    ICC/IF: 1/500 - 1/1000.
    IHC-P: 1/4000 - 1/8000.
    WB: 1/5000 - 1/10000. Predicted molecular weight: 50 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
    • 組織特異性
      Expressed in cells lacking fibronectin.
    • 関連疾患
      Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
    • 配列類似性
      Belongs to the intermediate filament family.
    • 翻訳後修飾
      Phosphorylated by PKN1.
    • 細胞内局在
      Cytoplasm. Associated with intermediate filaments.
    • Information by UniProt
    • 参照データベース
    • 別名
      • wu:fb34h11 antibody
      • ALXDRD antibody
      • cb345 antibody
      • etID36982.3 antibody
      • FLJ42474 antibody
      • FLJ45472 antibody
      • GFAP antibody
      • GFAP_HUMAN antibody
      • gfapl antibody
      • Glial fibrillary acidic protein antibody
      • Intermediate filament protein antibody
      • wu:fk42c12 antibody
      • xx:af506734 antibody
      • zgc:110485 antibody
      see all

    Anti-GFAP antibody 画像

    • ab90601, at a 1/4000 dilution, staining GFAP in paraffin embedded Human brain tissue (left image) by Immunohistochemistry. Right image shows negative control: 40X objective.
    • ab90601, at a 1/6000 dilution, staining GFAP in Rat brain tissue (left image) by Immunohistochemistry. Right image shows negative control, 40X objective.
    • ab90601, at a 1/500 dilution, staining GFAP in Human brain tissue by Immunofluorescence. 40X objective.
    • ab90601, at a 1/500 dilution, staining GFAP in Rat brain by Immunofluorescence. 40X objective.
    • Anti-GFAP antibody (ab90601) at 1/6000 dilution + Human brain homogenate at 5 µg

      Predicted band size : 50 kDa

    Anti-GFAP antibody (ab90601) 使用論文

    ab90601 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab90601.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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