製品の概要

  • 製品名Anti-GFAP antibody
    GFAP 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GFAP
  • 特異性ab124657 stains astrocytes, glial cells, ependymal cells and their corresponding tumors. In the peripheral nervous system, it stains Schwann cells, satellite and enteric glial cells. This antibody distinguishes neoplasm of astrocytes origin from other neoplasm of CNS.
  • アプリケーション適用あり: IHC-P, IHC-Fr, ICCmore details
  • 種交差性
    交差種: Mouse, Rat, Sheep, Goat, Guinea pig, Cow, Human, Pig
  • 免疫原

    Full length native Human GFAP protein (purified)

  • ポジティブ・コントロール
    • Human brain or astrocytoma tissue
  • 特記事項ab124657 is prediluted in a proprietry (green colored) buffer.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab124657 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/1.
IHC-Fr 1/1.
ICC 1/1.

ターゲット情報

  • 機能GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
  • 組織特異性Expressed in cells lacking fibronectin.
  • 関連疾患Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
  • 配列類似性Belongs to the intermediate filament family.
  • 翻訳後修飾Phosphorylated by PKN1.
  • 細胞内局在Cytoplasm. Associated with intermediate filaments.
  • Information by UniProt
  • 参照データベース
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Anti-GFAP antibody (ab124657) 使用論文

ab124657 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"