製品の概要

  • 製品名GF 109203X hydrochloride
  • 製品の詳細
    Potent, cell-permeable, ATP-competitive PKC inhibitor
  • 生理活性の詳細Potent, cell-permeable, ATP-competitive PKC inhibitor (IC50 values for PKC subtypes are 50 (α), 17 (βI), 16 (βII) and 20 nM (γ)). Inhibits PKC over other kinases (IC50 values are 50 nM (MAPKAP), 100 nM (p70 S6 kinase), 2 μM (cAMP-dependent protein kinase) and 0.7 μM (phosphorylase kinase)). Crosses the blood-brain barrier.
  • 精製度> 99%

製品の特性

  • 体系名3-[1-(Dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride
  • 分子量448.95
  • 構造式Chemical Structure
  • 分子式C25H24N4O2.HCl
  • CAS 番号176504-36-2
  • PubChem 登録番号6419775
  • 保存方法Store at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54.Cl
  • 由来

    Synthetic

  • 研究分野

    関連製品

    GF 109203X hydrochloride (ab120844) 使用論文

    This product has been referenced in:
    • Cheung HH  et al. Inhibition of protein kinase C reduces ischemia-induced tyrosine phosphorylation of the N-methyl-d-aspartate receptor. J Neurochem 86:1441-9 (2003). Read more (PubMed: 12950452) »
    • Alessi DR The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase. FEBS Lett 402:121-3 (1997). Read more (PubMed: 9037179) »
    • Toullec D  et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266:15771-81 (1991). Read more (PubMed: 1874734) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120844.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"