製品の概要

  • 製品名Anti-Gelsolin antibody
    Gelsolin 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Gelsolin
  • 特異性This antibody is expected to recognize both reported isoforms (NP_000168.1 and NP_937895.1).
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide:

    C-PRLKDKKMDAHP

    , corresponding to internal sequence amino acids 655-666 of Human Gelsolin

  • ポジティブ・コントロール
    • Human Spleen lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab53560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 86 kDa).

    Peptide ELISA: antibody detection limit dilution 1:128,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
    • 組織特異性Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
    • 関連疾患Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
    • 配列類似性Belongs to the villin/gelsolin family.
      Contains 6 gelsolin-like repeats.
    • 翻訳後修飾Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.
    • 細胞内局在Cytoplasm > cytoskeleton and Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Actin depolymerizing factor antibody
      • Actin-depolymerizing factor antibody
      • ADF antibody
      • AGEL antibody
      • Brevin antibody
      • DKFZp313L0718 antibody
      • GELS_HUMAN antibody
      • Gelsolin antibody
      • Gsn antibody
      see all

    Anti-Gelsolin antibody 画像

    Anti-Gelsolin antibody (ab53560) 使用論文

    ab53560 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab53560.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"