製品の概要

  • 製品名
    Geldanamycin
  • 製品の詳細
    Selective Hsp90 inhibitor
  • 生理活性の詳細
    Selective Hsp90 inhibitor. Binds the ATP site of Hsp90 and inhibits chaperone activity. A benzoquinone ansamycin antibiotic. Also inhibits the Hsp90 paralog GRP94. Exhibits various cellular actions including gene expression, cell proliferation, apoptosis and angiogenesis.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Lee CH  et al. Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells. Biochimie 94:1382-9 (2012). Read more (PubMed: 22445681) »
  • Roe SM  et al. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem 42:260-6 (1999). Read more (PubMed: 9925731) »
  • Whitesell L  et al. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A 91:8324-8 (1994). Read more (PubMed: 8078881) »

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