製品の概要

  • 製品名Anti-GDNF Receptor alpha 2 antibody
    GDNF Receptor alpha 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GDNF Receptor alpha 2
  • アプリケーション適用あり: ICC/IF, WB, IHC (PFA fixed)more details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Peptide corresponding to amino acids 377 to 391of human GFRa-2. The amino acid sequences ofimmunogenic peptide are identical to those of mouse andrat.

  • ポジティブ・コントロール
    • HeLa whole cell lysate
  • 特記事項

    Members of the glial cell line-derived neurotrophic factor(GDNF) family, including GDNF and neurturin (NTN),play key roles in the control of vertebrate neuron survivaland differentiation. Physiological responses to NTN requirethe presence of a novel glycosylphosphadidylinositollinked protein NTNRa, which is a cell surface receptor forNTN. The cDNAs encoding NTNRa from human, rat,chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2)or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal andto mediate NTN function.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C.
  • バッファーPBS with 0.02% sodium azide
  • Concentration information loading...
  • 精製度IgG fraction
  • 一次抗体 備考Members of the glial cell line-derived neurotrophic factor(GDNF) family, including GDNF and neurturin (NTN),play key roles in the control of vertebrate neuron survivaland differentiation. Physiological responses to NTN requirethe presence of a novel glycosylphosphadidylinositollinked protein NTNRa, which is a cell surface receptor forNTN. The cDNAs encoding NTNRa from human, rat,chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2)or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal andto mediate NTN function.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab8027 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 5 µg/ml.
WB Use at an assay dependent concentration. Can be blocked with Human GDNF Receptor alpha 2 peptide (ab39769).
IHC (PFA fixed) 1/50.

ターゲット情報

  • 機能Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
    Isoform 2: Participates to NRTN-induced 'Ser-727' phosphorylation of STAT3.
  • 組織特異性Isoform 1 is found in both brain and placenta.
  • 配列類似性Belongs to the GDNFR family.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • GDNF family receptor alpha 2 antibody
    • GDNF family receptor alpha-2 antibody
    • GDNF receptor alpha-2 antibody
    • GDNF receptor beta antibody
    • GDNFR beta antibody
    • GDNFR-alpha-2 antibody
    • GDNFR-beta antibody
    • GDNFRB antibody
    • GFR alpha 2 antibody
    • GFR-alpha-2 antibody
    • GFRA 2 antibody
    • Gfra2 antibody
    • GFRA2_HUMAN antibody
    • Glial cell line derived neurotrophic factor family receptor alpha2b antibody
    • Glial cell line derived neurotrophic factor receptor beta antibody
    • Neurturin receptor alpha antibody
    • NRTNR alpha antibody
    • NRTNR-alpha antibody
    • NTNR alpha antibody
    • NTNR-alpha antibody
    • NTNRA antibody
    • PI linked cell surface accessory protein antibody
    • PI linked cell-surface accessory protein antibody
    • RET ligand 2 antibody
    • RETL 2 antibody
    • RETL2 antibody
    • TGF beta related neurotrophic factor receptor 2 antibody
    • TGF-beta-related neurotrophic factor receptor 2 antibody
    • TRN receptor GPI anchored antibody
    • TRNR 2 antibody
    • TRNR2 antibody
    see all

Anti-GDNF Receptor alpha 2 antibody 画像

  • Anti-GDNF Receptor alpha 2 antibody (ab8027) at 1/1000 dilution + HeLa total cell lysate

    Observed band size : 52 kDa (why is the actual band size different from the predicted?)
  • ab8027 at 5µg/ml staining GDNF Receptor alpha2 in Hela cells by ICC/IF.

Anti-GDNF Receptor alpha 2 antibody (ab8027) 使用論文

This product has been referenced in:
  • Hai B  et al. Transient activation of hedgehog pathway rescued irradiation-induced hyposalivation by preserving salivary stem/progenitor cells and parasympathetic innervation. Clin Cancer Res 20:140-50 (2014). Read more (PubMed: 24150232) »
  • Wang K  et al. The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer. Carcinogenesis N/A:N/A (2013). IHC ; Human . Read more (PubMed: 24067900) »

See all 3 Publications for this product

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