製品の概要

  • 製品名
  • 製品の詳細
    Sheep polyclonal to GDNF
  • 特異性
    Cross reactivity: This antibody is known to react with human, mouse, rat and other rodents. Cross reactivity with other species has not been tested. No cross reactivity with NTN. GDNF homodimerizes and has 5 isoforms along with a signal and propeptide, so there is a potential for multiple bands in western blot.
  • アプリケーション
    適用あり: Dot blot, WB, IHC (PFA fixed)more details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant human Glial Derived Neurotrophic Factor.

  • 特記事項
    This antibody has been used successfully for immunohistochemistry, immunoblotting and quantitative 2- site ELISA.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab6206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Dot blot
WB
IHC (PFA fixed)
  • 追加情報
    Dot: 1/3000.
    Immunohistochemistry (PFA fixed): Use at an assay dependent dilution on 4% paraformaldehyde perfusion fixed tissue cut on cryostat. See protocols given in the book "Neurotrophin Protocols" edited by RA Rush and published by Humana Press. This book is volume 169 in the Methods in Molecular Biology series.
    WB: 1/3000.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
    • 組織特異性
      In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
    • 関連疾患
      Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
      Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
    • 配列類似性
      Belongs to the TGF-beta family. GDNF subfamily.
    • 細胞内局在
      Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Astrocyte derived trophic factor antibody
      • Astrocyte derived trophic factor 1 antibody
      • Astrocyte-derived trophic factor antibody
      • ATF 1 antibody
      • ATF 2 antibody
      • Atf antibody
      • ATF1 antibody
      • ATF2 antibody
      • gdnf antibody
      • GDNF_HUMAN antibody
      • Glial cell derived neurotrophic factor antibody
      • Glial Cell Line Derived Neurotrophic Factor antibody
      • Glial cell line-derived neurotrophic factor antibody
      • Glial derived neurotrophic factor antibody
      • HFB1 GDNF antibody
      • hGDNF antibody
      • HSCR3 antibody
      see all

    参考文献

    ab6206 has not yet been referenced specifically in any publications.

    レビューと Q&A

    I am very sorry to inform you that I have been unable to find out more information regarding our GDNF antibody ab6206 regarding the protocols used to test them in IHC. The academic scientist who has tested it seems to be unavailable. From his published...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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