製品の概要
- 製品名Anti-GDNF antibody
GDNF 一次抗体 製品一覧 - 製品の詳細Sheep polyclonal to GDNF
- 特異性Cross reactivity: This antibody is known to react with human, mouse, rat and other rodents. Cross reactivity with other species has not been tested. No cross reactivity with NTN. GDNF homodimerizes and has 5 isoforms along with a signal and propeptide, so there is a potential for multiple bands in western blot.
- アプリケーション適用あり: Dot blot, WB, IHC (PFA fixed)more details
- 種交差性交差種: Human
- 免疫原
Recombinant human Glial Derived Neurotrophic Factor.
- 特記事項This antibody has been used successfully for immunohistochemistry, immunoblotting and quantitative 2- site ELISA.
製品の特性
- 製品の状態Liquid
- 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
- 精製度Whole antiserum
- ポリ/モノポリクローナル
- アイソタイプIgG
- 研究分野
アプリケーション
Our Abpromise guarantee covers the use of ab6206 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Dot blot | ||
| WB | ||
| IHC (PFA fixed) |
Immunohistochemistry (PFA fixed): Use at an assay dependent dilution on 4% paraformaldehyde perfusion fixed tissue cut on cryostat. See protocols given in the book "Neurotrophin Protocols" edited by RA Rush and published by Humana Press. This book is volume 169 in the Methods in Molecular Biology series.
WB: 1/3000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
- 機能Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
- 組織特異性In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
- 関連疾患Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. - 配列類似性Belongs to the TGF-beta family. GDNF subfamily.
- 細胞内局在Secreted.
- Information by UniProt
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参照データベース
- Entrez Gene: 2668 Human
- Omim: 600837 Human
- SwissProt: P39905 Human
- Unigene: 248114 Human
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別名
- Astrocyte derived trophic factor antibody
- Astrocyte derived trophic factor 1 antibody
- Astrocyte-derived trophic factor antibody
see all
Anti-GDNF antibody (ab6206) 使用論文
ab6206 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"