製品の概要

  • 製品名Anti-GDNF antibody
    GDNF 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GDNF
  • 特異性GDNF homodimerizes and has 5 isoforms along with a signal and propeptide, so there is a potential for multiple bands in western blot.
  • アプリケーション適用あり: WB, IHC-P, ICCmore details
  • 種交差性
    交差種: Rat, Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide corresponding to an internal sequence of Human GDNF.

  • ポジティブ・コントロール
    • Rat brain tissue; Recombinant Human GDNF protein.

法規制情報

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab119473 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 24 kDa.

The detection limit for GDNF is approximately 2.5ng/lane under non-reducing and reducing conditions. GDNF homodimerizes and has 5 isoforms along with a signal and propeptide, so there is a potential for multiple bands in western blot.

IHC-P Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
ICC Use a concentration of 1 µg/ml.

ターゲット情報

  • 機能Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
  • 組織特異性In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
  • 関連疾患Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
    Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
  • 配列類似性Belongs to the TGF-beta family. GDNF subfamily.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Astrocyte derived trophic factor antibody
    • Astrocyte derived trophic factor 1 antibody
    • Astrocyte-derived trophic factor antibody
    • ATF 1 antibody
    • ATF 2 antibody
    • Atf antibody
    • ATF1 antibody
    • ATF2 antibody
    • gdnf antibody
    • GDNF_HUMAN antibody
    • Glial cell derived neurotrophic factor antibody
    • Glial Cell Line Derived Neurotrophic Factor antibody
    • Glial cell line-derived neurotrophic factor antibody
    • Glial derived neurotrophic factor antibody
    • HFB1 GDNF antibody
    • hGDNF antibody
    • HSCR3 antibody
    see all

Anti-GDNF antibody 画像

  • ab119473 at 1µg/ml staining GDNF in by Paraffin-embedded Rat brain tissue by Immunohistochemistry.
  • All lanes : Anti-GDNF antibody (ab119473) at 1 µg/ml

    Lane 1 : Recombinant Human GDNF protein at 0.01 µg
    Lane 2 : Recombinant Human GDNF protein at 0.005 µg
    Lane 3 : Recombinant Human GDNF protein at 0.0025 µg


    Predicted band size : 24 kDa

Anti-GDNF antibody (ab119473) 使用論文

ab119473 has not yet been referenced specifically in any publications.

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