製品の概要

  • 製品名Anti-GCDH antibody [3E9BA3BF5]
    GCDH 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [3E9BA3BF5] to GCDH
  • アプリケーション適用あり: ICC/IF, IP, In-Cell ELISA, Flow Cytmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Purified recombinant full length Human GCDH expressed in E.coli.

  • ポジティブ・コントロール
    • Fibroblast, HeLa, HepG2, and Rat Cardiomyocyte cells.
  • 特記事項

    Product was previously marketed under the MitoSciences sub-brand.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab112998 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 1 µg/ml.
IP Use at an assay dependent concentration.
In-Cell ELISA Use a concentration of 1 µg/ml. 0.1 µg/well.
Flow Cyt Use a concentration of 1 µg/ml. 0.1% Triton X-100 permeabilization recommended.



ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.
  • 組織特異性Isoform 1 and isoform 2 are expressed in fibroblasts and liver.
  • パスウェイAmino-acid metabolism; lysine degradation.
    Amino-acid metabolism; tryptophan metabolism.
  • 関連疾患Defects in GCDH are the cause of glutaric aciduria type 1 (GA1) [MIM:231670]. GA1 is an autosomal recessive metabolic disorder characterized by progressive dystonia and athetosis due to gliosis and neuronal loss in the basal ganglia.
  • 配列類似性Belongs to the acyl-CoA dehydrogenase family.
  • 細胞内局在Mitochondrion matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ACAD5 antibody
    • EC 1.3.99.7 antibody
    • GCD antibody
    • Gcdh antibody
    • GCDH_HUMAN antibody
    • Glutaryl CoA dehydrogenase antibody
    • Glutaryl CoA dehydrogenase, mitochondrial antibody
    • Glutaryl Coenzyme A dehydrogenase antibody
    • Glutaryl-CoA dehydrogenase antibody
    • mitochondrial antibody
    • MS781 antibody
    see all

Anti-GCDH antibody [3E9BA3BF5] 画像

  • ab112998 at 1 µg/ml staining GCDH in fibroblast cells by immunocytochemistry (4% paraformaldehyde fixed and 0.1% Triton X-100 permeabilized) followed by Alexa Fluor® 594 goat anti-mouse IgG (H+L) used at a 1/1000 dilution for 1 hour (red). Nuclei were stained with DAPI.
  • ab112998 at 1ug/ml staining GCDH in HeLa cells by Flow Cytometry (blue). Isotype control antibody (red).

Anti-GCDH antibody [3E9BA3BF5] (ab112998) 使用論文

ab112998 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"