製品の概要

  • 製品名Anti-GCAP2 antibody [A1]
    GCAP2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [A1] to GCAP2
  • 特異性This antibody is specific for GCAP 2 and does not react with other isotypes.
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Cow
  • 免疫原

    Other Immunogen Type corresponding to GCAP2. Bacterial expressed full length GCAP2.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.05% Sodium azide
    Constituents: 99% PBS, 0.1% BSA
  • Concentration information loading...
  • 精製度Protein A purified
  • 一次抗体 備考Guanylate cyclase-activating proteins (GCAPs) are calcium binding proteins that belong to the calmodulin superfamily. GCAPs without calcium are responsible for activation of photoreceptor guanylate cyclase during light adaptation. Studies have shown that the addition or subtraction of Ca2+ results in major conformational changes and the activation/deactivation of GCAP 1 and GCAP 2. It has been demonstrated that both GCAP 1 and 2 act on guanylate cyclase similarly and have approximately 50% homology between the two forms. GCAP-1 is predominantly localized in the photoreceptor outer segments, while GCAP 2 is found in retina samples.
  • ポリ/モノモノクローナル
  • クローン名A1
  • アイソタイプIgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab5422 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent dilution.
WB Use a concentration of 1 µg/ml. Detects a band of approximately 23 kDa.

ターゲット情報

  • 機能Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.
  • 組織特異性Retina. Cones and rod.
  • 配列類似性Contains 4 EF-hand domains.
  • 細胞内局在Cell membrane. Membranes of outer segment.
  • Information by UniProt
  • 参照データベース
  • 別名
    • GCAP 2 antibody
    • Guanylate Cyclase Activating Protein Photoreceptor 2 antibody
    • Guanylate cyclase activator 1B antibody
    • Guanylin 2 antibody
    • Guanylyl cyclase-activating protein 2 antibody
    • GUC1B_HUMAN antibody
    • GUCA 2 antibody
    • Guca1b antibody
    see all

Anti-GCAP2 antibody [A1] 画像

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    Western blot of GCAP 2 on bovine rod outer segment lysate using ab5422.

Anti-GCAP2 antibody [A1] (ab5422) 使用論文

ab5422 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. Both of these antibodies have been made against the full length GCAP1 and full length GCAP2 proteins. These antibodies have not been epitope mapped, and therefore we do not know the exact peptide sequence that the anti-GCAP...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"