製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-DAEAYRHSPVFQ
    • 領域65 to 76

関連製品

特性

Our Abpromise guarantee covers the use of ab45795 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-GATA1 antibody (ab40847)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • Anemia, X-linked, without thrombocytopenia, included
    • ERYF 1
    • Eryf1
    • Erythroid transcription factor
    • Erythrold transcription factor 1
    • GATA 1
    • GATA binding factor 1
    • GATA binding protein 1
    • GATA binding protein 1 (globin transcription factor 1)
    • GATA-1
    • GATA-binding factor 1
    • GATA1
    • GATA1_HUMAN
    • GF 1
    • GF-1
    • GF1
    • Globin transcription factor 1
    • NF E1
    • NF E1 DNA binding protein
    • NF-E1 DNA-binding protein
    • NFE 1
    • NFE1
    • Nuclear factor erythroid 1
    • Transcription factor GATA1
    • XLANP
    • XLTDA
    • XLTT
    see all
  • 機能Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells.
  • 組織特異性Erythrocytes.
  • 関連疾患Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.
    Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050]; also knwon as thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis. XLTT consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced hemoglobin chain synthesis resembling that of beta-thalassemia minor.
    Defects in GATA1 are the cause of anemia without thrombocytopenia X-linked (XLAWT) [MIM:300835]. XLAWT is a form of anemia characterized by abnormal morphology of erythrocytes and granulocytes in peripheral blood, bone marrow dysplasia with hypocellularity of erythroid and granulocytic lineages, and normal or increased number of megakaryocytes. Neutropenia of a variable degree is present in affected individuals.
  • 配列類似性Contains 2 GATA-type zinc fingers.
  • ドメインThe two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding.
  • 翻訳後修飾Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137.
    Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation by SUMO1 has no effect on transcriptional activity.
  • 細胞内局在Nucleus.
  • Information by UniProt

GATA1 peptide (65-76) (ab45795) 使用論文

ab45795 has not yet been referenced specifically in any publications.

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