製品の概要

  • 製品名Anti-Gastrin antibody
    Gastrin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Gastrin
  • 特異性This antibody detects Gastrin
  • アプリケーション適用あり: Dot blot, IHC-Fr, IHC-P, WBmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: all Mammals
  • 免疫原

    Human gastrin 17 conjugated to BSA.

  • ポジティブ・コントロール
    • Antrum.
  • 特記事項Gastrin secreting cells are numerous in the antrum and few are found in the proximal duodenum.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab8492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Dot blot Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.
WB Use at an assay dependent concentration.

ターゲット情報

  • 機能Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
  • 配列類似性Belongs to the gastrin/cholecystokinin family.
  • 翻訳後修飾Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
    Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Component II antibody
    • G14 antibody
    • G17 antibody
    • G34 antibody
    • G52 antibody
    • G6 antibody
    • GAS antibody
    • Gast antibody
    • GAST_HUMAN antibody
    • Gastrin antibody
    • Gastrin component I antibody
    • Gastrin component II antibody
    • Gastrin component III antibody
    • Gastrin precursor antibody
    • Gastrin-14 antibody
    • Gastrin-17 antibody
    • Gastrin-34 antibody
    • Gastrin-52 antibody
    • Gastrin-6 antibody
    • Gastrin-71 antibody
    see all

Anti-Gastrin antibody (ab8492) 使用論文

This product has been referenced in:
  • Gonzalez-Coto AF  et al. Expression of cholecystokinin, gastrin, and their receptors in the mouse cornea. Invest Ophthalmol Vis Sci 55:1965-75 (2014). Mouse . Read more (PubMed: 24576871) »

See 1 Publication for this product

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Thank you for your enquiry. I have contacted the originator of the product but unfortunately the information about the immunogen sequence and the location of the antigen is unknown. I am sorry that we can not be of any further help.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"