製品の概要

  • 製品名Anti-Gastrin antibody
    Gastrin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Gastrin
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Horse, Dog
  • 免疫原

    Synthetic peptide:

    MQRLCVYVLIFAL

    conjugated to BSA, corresponding to N terminal amino acids 1-13 of Human Gastrin.

  • ポジティブ・コントロール
    • Pituitary or stomach
  • 特記事項


    This antibody may be used to study the differential tissue expression and intracellular and subcellular localization of gastrin in neuroendocrine cells of the gastrointestinal tract,and in the CNS. Antibodies to gastrin are also useful for the identificationand detection of gastrin in normal and neoplastic tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab16035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/200.

ターゲット情報

  • 機能Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
  • 配列類似性Belongs to the gastrin/cholecystokinin family.
  • 翻訳後修飾Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
    Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Component II antibody
    • G14 antibody
    • G17 antibody
    • G34 antibody
    • G52 antibody
    • G6 antibody
    • GAS antibody
    • Gast antibody
    • GAST_HUMAN antibody
    • Gastrin antibody
    • Gastrin component I antibody
    • Gastrin component II antibody
    • Gastrin component III antibody
    • Gastrin precursor antibody
    • Gastrin-14 antibody
    • Gastrin-17 antibody
    • Gastrin-34 antibody
    • Gastrin-52 antibody
    • Gastrin-6 antibody
    • Gastrin-71 antibody
    see all

Anti-Gastrin antibody 画像

  • ab16035 staining human Gastrin at 1/200 dilution in stomach by Immunohistochemistry (FFPE-sections).

Anti-Gastrin antibody (ab16035) 使用論文

This product has been referenced in:
  • Lennerz JK  et al. The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma. Am J Pathol 177:1514-33 (2010). IHC-P ; Human . Read more (PubMed: 20709804) »

See 1 Publication for this product

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We do not have any experimental data regarding the cross-reactivity of ab16035 with CCK. I compared the immunogen sequence for ab16035 with that of the CCK sequence (P06307-Uniprot) and the percentage homology is ...

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Thank you for contacting us.

We have not experimentally tested the possibility of ab16035 cross reactivity with CCK. So I am sorry we cannot confirm it 100%. The recommendations we gave were based on the minimal sequence homology between CCK...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"