製品の概要

  • 製品名
    GANT58
  • 製品の詳細
    Downstream Hh signaling inhibitor
  • 生理活性の詳細
    Inhibits Hh signaling downstream of smo and sufu. IC50 = 5 μM for glioma associated oncogene expression in MEFs.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Stanton BZ & Peng LF Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst 6:44-54 (2010). Read more (PubMed: 20024066) »
  • Katoh Y & Katoh M Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med 9:873-86 (2009). Read more (PubMed: 19860666) »
  • Lauth M  et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A 104:8455-60 (2007). Read more (PubMed: 17494766) »

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