製品の概要

  • 製品名Anti-gamma Synuclein antibody
    gamma Synuclein 一次抗体 製品一覧
  • 製品の詳細
    Sheep polyclonal to gamma Synuclein
  • 特異性The peptide sequence was chosen to achieve a high level of specificity in the antiserum. Specificity also has been demonstrated by immunohistochemistry and western blot.
  • アプリケーション適用あり: WB, ELISA, IHC-Frmore details
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    Synthetic peptide:

    EKEEVAEEAQSGGD

    , corresponding to C terminal amino acids 114-127 of Human gamma Synuclein. This peptide was conjugated to carrier protein to enhance the immunological response.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab49206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 3 µg/ml. Predicted molecular weight: 13 kDa.
ELISA Use a concentration of 1 µg/ml.
IHC-Fr Use a concentration of 3 - 5 µg/ml.

ターゲット情報

  • 機能Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.
  • 組織特異性Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
  • 配列類似性Belongs to the synuclein family.
  • 翻訳後修飾Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
  • 細胞内局在Cytoplasm > perinuclear region. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BCSG1 antibody
    • Breast cancer specific gene 1 protein antibody
    • Breast cancer specific protein 1 antibody
    • Breast cancer-specific gene 1 protein antibody
    • Gamma synuclein antibody
    • Gamma-synuclein antibody
    • Persyn antibody
    • PRSN antibody
    • SNCG antibody
    • SR antibody
    • Synoretin antibody
    • Synuclein gamma antibody
    • synuclein, gamma (breast cancer-specific protein 1) antibody
    • SYUG_HUMAN antibody
    see all

Anti-gamma Synuclein antibody (ab49206) 使用論文

This product has been referenced in:
  • Wilding C  et al. ?-Synuclein antibodies have neuroprotective potential on neuroretinal cells via proteins of the mitochondrial apoptosis pathway. PLoS One 9:e90737 (2014). Read more (PubMed: 24595072) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"