製品の概要

  • 製品名Anti-GALNT12 antibody
    GALNT12 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GALNT12
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Cow
  • 免疫原

    Recombinant fragment, corresponding to a region within internal sequence amino acids 34-173 of Human GALNT12 (AAH13945; UniProt ID: Q8IXK2 isoform 2).

  • ポジティブ・コントロール
    • A549 whole cell lysate

法規制情報

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab101358 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: for isoform 2, 32 kDa.

ターゲット情報

  • 機能Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.
  • 組織特異性Widely expressed at different levels of expression. Highly expressed in digestive organs such as small intestine, stomach, pancreas and colon. Expressed at intermediate level in testis, thyroid gland and spleen. Weakly expressed in whole brain, cerebral cortex, cerebellum, fetal brain, bone marrow, thymus, leukocytes, heart, skeletal muscle, liver, lung, esophagus, kidney, adrenal gland, mammary gland, uterus, placenta, ovary and prostate.
  • パスウェイProtein modification; protein glycosylation.
  • 関連疾患Defects in GALNT12 are a cause of susceptibility to colorectal cancer type 1 (CRCS1) [MIM:608812]. Colorectal cancer is a malignancy originating either in the colon or rectum or both.
  • 配列類似性Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
    Contains 1 ricin B-type lectin domain.
  • ドメインThere are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
    The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • 細胞内局在Golgi apparatus membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Colorectal cancer susceptibility to 1 antibody
    • CRCS1 antibody
    • FLJ21212 antibody
    • GalNAc T12 antibody
    • GalNAc-T12 antibody
    • GalNAcT12 antibody
    • GALNT 12 antibody
    • Galnt12 antibody
    • GLT12_HUMAN antibody
    • Polypeptide GalNAc transferase 12 antibody
    • Polypeptide N acetylgalactosaminyltransferase 12 antibody
    • Polypeptide N-acetylgalactosaminyltransferase 12 antibody
    • pp GaNTase 12 antibody
    • pp-GaNTase 12 antibody
    • Protein UDP acetylgalactosaminyltransferase 12 antibody
    • Protein-UDP acetylgalactosaminyltransferase 12 antibody
    • UDP GalNAc polypeptide N acetylgalactosaminyltransferase 12 antibody
    • UDP GalNAc polypeptide N acetylgalactosaminyltransferase antibody
    • UDP N acetyl alpha D galactosamine polypeptide N acetylgalactosaminyltransferase 12 antibody
    • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12 antibody
    see all

Anti-GALNT12 antibody 画像

  • Anti-GALNT12 antibody (ab101358) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : for isoform 2, 32 kDa

Anti-GALNT12 antibody (ab101358) 使用論文

ab101358 has not yet been referenced specifically in any publications.

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