製品の概要

  • 製品名Anti-GALE antibody
    GALE 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to GALE
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length GALE protein (Human)

  • ポジティブ・コントロール
    • Human colon tissue lysate. GALE transfected 293T cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab67389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa).

ターゲット情報

  • 機能Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.
  • パスウェイCarbohydrate metabolism; galactose metabolism.
  • 関連疾患Defects in GALE are the cause of epimerase-deficiency galactosemia (EDG) [MIM:230350]; also known as galactosemia type 3. Clinical features include early-onset cataracts, liver damage, deafness and mental retardation. There are two clinically distinct forms of EDG. (1) A benign, or 'peripheral' form with no detectable GALE activity in red blood cells and characterized by mild symptoms. Some patients may suffer no symptoms beyond raised levels of galactose-1-phosphate in the blood. (2) A much rarer 'generalized' form with undetectable levels of GALE activity in all tissues and resulting in severe features such as restricted growth and mental development.
  • 配列類似性Belongs to the sugar epimerase family.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ95174 antibody
    • FLJ97302 antibody
    • Galactose 4 epimerase UDP antibody
    • Galactowaldenase antibody
    • galE antibody
    • GALE_HUMAN antibody
    • OTTHUMP00000002991 antibody
    • OTTHUMP00000002994 antibody
    • OTTHUMP00000037931 antibody
    • OTTHUMP00000044857 antibody
    • SDR1E1 antibody
    • short chain dehydrogenase/reductase family 1E member 1 antibody
    • UDP galactose 4 epimerase antibody
    • UDP galactose 4' epimerase antibody
    • UDP glucose 4 epimerase antibody
    • UDP-galactose 4-epimerase antibody
    • UDP-glucose 4-epimerase antibody
    see all

Anti-GALE antibody 画像

  • Anti-GALE antibody (ab67389) at 1/500 dilution + Human colon tissue lysate at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa
  • All lanes : Anti-GALE antibody (ab67389) at 1/500 dilution

    Lane 1 : GALE transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa

Anti-GALE antibody (ab67389) 使用論文

This product has been referenced in:
  • Deng Y  et al. The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. J Clin Invest 123:455-68 (2013). WB ; Mouse . Read more (PubMed: 23257357) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"