製品の概要

  • 製品名
    Gaboxadol hydrochloride (THIP hydrochloride)
  • 製品の詳細
    GABAA receptor agonist and GABAC receptor antagonist
  • 生理活性の詳細
    GABAA receptor agonist and GABAC receptor antagonist. Antinociceptive, anticonvulsant and hypnotic agent. Blood-brain barrier permeable. Active in vivo and in vitro.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Morishita W & Sastry BR Postsynaptic mechanisms underlying long-term depression of GABAergic transmission in neurons of the deep cerebellar nuclei. J Neurophysiol 76:59-68 (1996). Read more (PubMed: 8836209) »
  • Johnston GA GABAc receptors: relatively simple transmitter -gated ion channels? Trends Pharmacol Sci 17:319-23 (1996). Read more (PubMed: 8885697) »
  • Krogsgaard-Larsen P  et al. 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. J Med Chem 26:895-900 (1983). Read more (PubMed: 6304315) »

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