Anti-GABA B Receptor 2 (phospho S783) 抗体 (ab72447)

製品の概要

  • 製品名Anti-GABA B Receptor 2 (phospho S783) antibody
    GABA B Receptor 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GABA B Receptor 2 (phospho S783)
  • 特異性ab72447 recognises GABA B Receptor 2 when phosphorylated at Ser 783.
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Rat
    交差が予測される動物種: Mouse, Chicken, Cow, Human, Xenopus laevis, Non Human Primates
  • 免疫原

    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser783 of rat GABA B Receptor 2.

  • ポジティブ・コントロール
    • rat synaptic membrane

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab72447 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa).
ICC/IF 1/500.

ターゲット情報

  • 機能Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
  • 組織特異性Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
  • 配列類似性Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
  • ドメインAlpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
  • 細胞内局在Cell membrane. Cell junction > synapse > postsynaptic cell membrane. Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
  • Information by UniProt
  • 参照データベース
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Anti-GABA B Receptor 2 (phospho S783) antibody 画像

  • All lanes : Anti-GABA B Receptor 2 (phospho S783) antibody (ab72447) at 1/1000 dilution

    Lane 1 : rat synaptic membrane
    Lane 2 : rat synaptic membrane pre-incubated in lambda-Phosphatase (1200 units for 30 min)


    Predicted band size : 106 kDa
    Observed band size : 106 kDa

Anti-GABA B Receptor 2 (phospho S783) antibody (ab72447) 使用論文

ab72447 has not yet been referenced specifically in any publications.

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