製品の概要

  • 製品名
    Anti-GABA B Receptor 2 antibody
    GABA B Receptor 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GABA B Receptor 2
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 761-810 (

    QFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLE

    ) of Human GABBR2 (NP_005449).

  • ポジティブ・コントロール
    • HeLa cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115929 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 106 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
  • 組織特異性
    Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
  • 配列類似性
    Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
  • ドメイン
    Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
  • 細胞内局在
    Cell membrane. Cell junction > synapse > postsynaptic cell membrane. Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BcDNA:GH07312 antibody
    • CG6706 antibody
    • CT20836 antibody
    • D Gaba2 antibody
    • FLJ36928 antibody
    • G protein coupled receptor 51 antibody
    • G-protein coupled receptor 51 antibody
    • GAB B R2 antibody
    • GABA B R2 antibody
    • GABA B receptor 2 antibody
    • GABA-B receptor 2 antibody
    • GABA-B-R2 antibody
    • GABA-BR2 antibody
    • GABAB R2 antibody
    • GABABR 2 antibody
    • GABABR2 antibody
    • GABB R2 antibody
    • GABBR 2 antibody
    • Gabbr2 antibody
    • GABR2_HUMAN antibody
    • Gamma aminobutyric acid B receptor 2 antibody
    • Gamma aminobutyric acid GABA B receptor 2 antibody
    • Gamma aminobutyric acid type B receptor subunit 2 antibody
    • Gamma-aminobutyric acid type B receptor subunit 2 antibody
    • Gb 2 antibody
    • Gb2 antibody
    • GH07312 antibody
    • GPR 51 antibody
    • GPR51 antibody
    • GPRC 3B antibody
    • GPRC3B antibody
    • HG 20 antibody
    • HG20 antibody
    • HRIHFB2099 antibody
    • Metabotropic GABA B receptor subtype 2 antibody
    • OTTHUMP00000021776 antibody
    • OTTHUMP00000063797 antibody
    • R2 SUBUNIT antibody
    see all

画像

  • Anti-GABA B Receptor 2 antibody (ab115929) at 1 µg/ml + HeLa cell lysate at 10 µg

    Predicted band size : 106 kDa

プロトコール

参考文献

ab115929 has not yet been referenced specifically in any publications.

レビューと Q&A

There are currently no Customer reviews or Questions for ab115929.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録