Anti-GABA A Receptor gamma 2 (phospho S327) 抗体 (ab73183)


  • 製品名Anti-GABA A Receptor gamma 2 (phospho S327) antibody
    GABA A Receptor gamma 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GABA A Receptor gamma 2 (phospho S327)
  • 特異性ab73183 is specific for ~45kDa GABA A Receptor gamma 2 subunit phosphorylated at Ser327. Immunolabeling of the GABA A Receptor gamma 2 band is completely blocked by lambda phosphatase treatment.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Rat
    交差が予測される動物種: Mouse, Chicken, Cow, Dog, Human, Non Human Primates
  • 免疫原

    Synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser327 of GABA A Receptor gamma 2.

  • ポジティブ・コントロール
    • Rat cortex.


  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 50% Glycerol, 100µg/ml BSA, 150mM Sodium chloride, 10mM HEPES, pH 7.5
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab73183 is prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野


Our Abpromise guarantee covers the use of ab73183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Detects a band of approximately 50 kDa (predicted molecular weight: 54 kDa).


  • 機能GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 関連疾患Defects in GABRG2 are the cause of childhood absence epilepsy type 2 (ECA2) [MIM:607681]. ECA2 is a subtype of idiopathic generalized epilepsy (IGE) characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Some individuals manifest ECA2 occurring in combination with febrile convulsions.
    Defects in GABRG2 are the cause of familial febrile convulsions type 8 (FEB8) [MIM:611277]. A febrile convulsion is defined as a seizure event in infancy or childhood, usually occurring between 6 months and 6 years of age, associated with fever but without any evidence of intracranial infection or defined pathologic or traumatic cause. Febrile convulsions affect 5-12% of infants and children up to 6 years of age. There is epidemiological evidence that febrile seizures are associated with subsequent afebrile and unprovoked seizures in 2% to 7% of patients.
    Defects in GABRG2 are the cause of generalized epilepsy with febrile seizures plus type 3 (GEFS+3) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
    Defects in GABRG2 are a cause of severe myoclonic epilepsy in infancy (SMEI) [MIM:607208]; also called Dravet syndrome. SMEI is a rare disorder characterized by generalized tonic, clonic, and tonic-clonic seizures that are initially induced by fever and begin during the first year of life. Later, patients also manifest other seizure types, including absence, myoclonic, and simple and complex partial seizures. Psychomotor development delay is observed around the second year of life. SMEI is considered to be the most severe phenotype within the spectrum of generalized epilepsies with febrile seizures-plus.
  • 配列類似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
  • 翻訳後修飾Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability.
  • 細胞内局在Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CAE 2 antibody
    • CAE2 antibody
    • ECA 2 antibody
    • ECA2 antibody
    • GABA(A) receptor gamma 2 antibody
    • GABA(A) receptor subunit gamma 2 antibody
    • GABA(A) receptor subunit gamma-2 antibody
    • GABRG 2 antibody
    • GABRG2 antibody
    • Gamma aminobutyric acid (GABA) A receptor gamma 2 antibody
    • Gamma aminobutyric acid A receptor gamma 2 antibody
    • Gamma aminobutyric acid receptor gamma 2 subunit antibody
    • Gamma-aminobutyric acid receptor subunit gamma-2 antibody
    • GBRG2_HUMAN antibody
    • GEFSP 3 antibody
    • GEFSP3 antibody
    see all

Anti-GABA A Receptor gamma 2 (phospho S327) antibody 画像

  • All lanes : Anti-GABA A Receptor gamma 2 (phospho S327) antibody (ab73183) at 1/1000 dilution

    Lane 1 : Rat cortex
    Lane 2 : Rat cortex with immunising peptide

    Predicted band size : 54 kDa
    Observed band size : 50 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 100 kDa,95 kDa. We are unsure as to the identity of these extra bands.

Anti-GABA A Receptor gamma 2 (phospho S327) antibody (ab73183) 使用論文

ab73183 has not yet been referenced specifically in any publications.

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