Anti-GABA A Receptor gamma 2 抗体 - Extracellular domain (ab49961)

製品の概要

  • 製品名Anti-GABA A Receptor gamma 2 antibody - Extracellular domain
    GABA A Receptor gamma 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GABA A Receptor gamma 2 - Extracellular domain
  • アプリケーション適用あり: WB, IHC-Frmore details
  • 種交差性
    交差種: Mouse, Rat, Cow, Human
    交差が予測される動物種: Chicken
  • 免疫原

    Synthetic peptide:

    QKSDDDYEDYASNKT(C)

    , corresponding to N terminal amino acids 40-54 of rat GABA A Receptor gamma 2

  • ポジティブ・コントロール
    • Rat brain membrane extracts and rat brain formalin-fixed frozen sections

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab49961 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-Fr
  • 追加情報IHC-Fr: Use at an assay dependent dilution.
    Note: use paraformaldehyde as fixative
    WB: 1/200. Predicted molecular weight: 54 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
    • 関連疾患Defects in GABRG2 are the cause of childhood absence epilepsy type 2 (ECA2) [MIM:607681]. ECA2 is a subtype of idiopathic generalized epilepsy (IGE) characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Some individuals manifest ECA2 occurring in combination with febrile convulsions.
      Defects in GABRG2 are the cause of familial febrile convulsions type 8 (FEB8) [MIM:611277]. A febrile convulsion is defined as a seizure event in infancy or childhood, usually occurring between 6 months and 6 years of age, associated with fever but without any evidence of intracranial infection or defined pathologic or traumatic cause. Febrile convulsions affect 5-12% of infants and children up to 6 years of age. There is epidemiological evidence that febrile seizures are associated with subsequent afebrile and unprovoked seizures in 2% to 7% of patients.
      Defects in GABRG2 are the cause of generalized epilepsy with febrile seizures plus type 3 (GEFS+3) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
      Defects in GABRG2 are a cause of severe myoclonic epilepsy in infancy (SMEI) [MIM:607208]; also called Dravet syndrome. SMEI is a rare disorder characterized by generalized tonic, clonic, and tonic-clonic seizures that are initially induced by fever and begin during the first year of life. Later, patients also manifest other seizure types, including absence, myoclonic, and simple and complex partial seizures. Psychomotor development delay is observed around the second year of life. SMEI is considered to be the most severe phenotype within the spectrum of generalized epilepsies with febrile seizures-plus.
    • 配列類似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
    • 翻訳後修飾Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability.
    • 細胞内局在Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CAE 2 antibody
      • CAE2 antibody
      • ECA 2 antibody
      • ECA2 antibody
      • GABA(A) receptor gamma 2 antibody
      • GABA(A) receptor subunit gamma 2 antibody
      • GABA(A) receptor subunit gamma-2 antibody
      • GABRG 2 antibody
      • GABRG2 antibody
      • Gamma aminobutyric acid (GABA) A receptor gamma 2 antibody
      • Gamma aminobutyric acid A receptor gamma 2 antibody
      • Gamma aminobutyric acid receptor gamma 2 subunit antibody
      • Gamma-aminobutyric acid receptor subunit gamma-2 antibody
      • GBRG2_HUMAN antibody
      • GEFSP 3 antibody
      • GEFSP3 antibody
      see all

    Anti-GABA A Receptor gamma 2 antibody - Extracellular domain (ab49961) 使用論文

    ab49961 has not yet been referenced specifically in any publications.

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