製品の概要

  • 製品名
    Anti-GABA A Receptor alpha 1 antibody
    GABA A Receptor alpha 1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to GABA A Receptor alpha 1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Rat, Cow, Human
  • 免疫原

    Fusion protein from the cytoplasmic loop of the alpha1-subunit of rat GABAA Receptor

  • ポジティブ・コントロール
    • Rat, bovine, human and mouse brain extracts

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab32589 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).

ターゲット情報

  • 機能
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 関連疾患
    Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4) [MIM:611136]. A subtype of idiopathic generalized epilepsy characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures may develop. Absence seizures may either remit or persist into adulthood.
    Defects in GABRA1 are the cause of juvenile myoclonic epilepsy type 5 (EJM5) [MIM:611136]. A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
  • 配列類似性
    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
  • 細胞内局在
    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ECA4 antibody
    • EIEE19 antibody
    • EJM antibody
    • EJM5 antibody
    • Gaba receptor alpha 1 polypeptide antibody
    • GABA(A) receptor antibody
    • GABA(A) receptor subunit alpha 1 antibody
    • GABA(A) receptor subunit alpha-1 antibody
    • GABA(A) receptor, alpha 1 antibody
    • GABRA 1 antibody
    • GABRA1 antibody
    • Gamma aminobutyric acid (GABA) A receptor alpha 1 antibody
    • Gamma aminobutyric acid A receptor alpha 1 antibody
    • Gamma aminobutyric acid receptor subunit alpha 1 antibody
    • Gamma aminobutyric acid type A receptor alpha1 subunit antibody
    • Gamma-aminobutyric acid receptor subunit alpha-1 antibody
    • GBRA1_HUMAN antibody
    see all

画像

  • All lanes : Anti-GABA A Receptor alpha 1 antibody (ab32589) at 1/1000 dilution

    Lane 1 : Wildtype forebrain lysates 5-7 ug
    Lane 2 : a1 knockout forebrain lysates 5-7 ug


    Predicted band size : 51 kDa
    Observed band size : 51 kDa

プロトコール

参考文献

This product has been referenced in:
  • Gao M  et al. Rebound potentiation of inhibition in juvenile visual cortex requires vision-induced BDNF expression. J Neurosci 34:10770-9 (2014). Read more (PubMed: 25100608) »

See 1 Publication for this product

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