製品の概要

  • 製品名Anti-FZD3 antibody
    FZD3 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to FZD3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 55-158 of Human FZD3

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab56331 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
    • 組織特異性Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.
    • 配列類似性Belongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • ドメインLys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
      The FZ domain is involved in binding with Wnt ligands.
    • 細胞内局在Membrane. Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Frizzled 3 antibody
      • Frizzled 3 seven transmembrane spanning receptor antibody
      • Frizzled family receptor 3 antibody
      • Frizzled homolog 3 (Drosophila) antibody
      • Frizzled homolog 3 antibody
      • Frizzled-3 antibody
      • Frizzled3 antibody
      • Fz 3 antibody
      • Fz-3 antibody
      • Fz3 antibody
      • FZD 3 antibody
      • Fzd3 antibody
      • FZD3_HUMAN antibody
      • hFz 3 antibody
      • hFz3 antibody
      see all

    Anti-FZD3 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab56331 FZD3 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-FZD3 antibody (ab56331) 使用論文

    This product has been referenced in:
    • Valastyan S  et al. A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell 137:1032-46 (2009). WB ; Human . Read more (PubMed: 19524507) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab56331.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"