製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to FUCA1
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region of Human FUCA1

  • ポジティブ・コントロール
    • Fetal liver lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab76400 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 54 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay, 1:312500.

ターゲット情報

  • 機能
    Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
  • 関連疾患
    Defects in FUCA1 are the cause of fucosidosis (FUCA1D) [MIM:230000]. FUCA1D is an autosomal recessive lysosomal storage disease characterized by accumulation of fucose-containing glycolipids and glycoproteins in various tissues. Clinical signs include facial dysmorphism, dysostosis multiplex, moderate hepatomegaly, severe intellectual deficit, deafness, and according to age, angiokeratomas.
  • 配列類似性
    Belongs to the glycosyl hydrolase 29 family.
  • 細胞内局在
    Lysosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Alpha L fucosidase I antibody
    • Alpha L fucoside fucohydrolase antibody
    • Alpha-L-fucosidase 1 antibody
    • Alpha-L-fucosidase I antibody
    • Alpha-L-fucoside fucohydrolase 1 antibody
    • FUCA antibody
    • FUCA1 antibody
    • FUCO_HUMAN antibody
    • fucosidase, alpha-L, tissue antibody
    • fucosidase, alpha-L- 1, tissue antibody
    • Tissue alpha L fucosidase antibody
    • Tissue alpha-L-fucosidase antibody
    see all

画像

  • Anti-FUCA1 antibody (ab76400) at 1 µg/ml (in 5% skim milk / PBS buffer) + fetal liver lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 54 kDa
    Observed band size : 54 kDa

プロトコール

参考文献

This product has been referenced in:

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