製品の概要

  • 製品名Anti-FTO antibody
    FTO 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FTO
  • アプリケーション適用あり: ICC/IF, WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    15 amino acid peptide from near the amino terminus of Human FTO.

  • ポジティブ・コントロール
    • Human uterus tissue lysate Mouse brain tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106386 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 58 kDa.
IHC-P Use a concentration of 2.5 µg/ml.

ターゲット情報

  • 機能Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
  • 組織特異性Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.
  • 関連疾患Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GRDDCFED) [MIM:612938]. The disease consists of a severe children multiple congenital anomaly syndrome with death by the age of 3 years. All affected individuals had postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits, and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate were also observed.
  • 配列類似性Belongs to the fto family.
  • ドメイ���The 3D-structure of the Fe2OG dioxygenase domain is similar to that of the Fe2OG dioxygenase domain found in the bacterial DNA repair dioxygenase alkB and its mammalian orthologs, but sequence similarity is very low. As a consequence, the domain is not detected by protein signature databases.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AlkB homolog 9 antibody
    • ALKBH9 antibody
    • Alpha-ketoglutarate-dependent dioxygenase FTO antibody
    • AW743446 antibody
    • Fat mass and obesity-associated protein antibody
    • FATSO, MOUSE, HOMOLOG OF antibody
    • Fto antibody
    • FTO_HUMAN antibody
    • GDFD antibody
    • KIAA1752 antibody
    • mKIAA1752 antibody
    • Protein fatso antibody
    see all

Anti-FTO antibody 画像

  • Lane 1 : Anti-FTO antibody (ab106386) at 1 µg/ml
    Lane 2 : Anti-FTO antibody (ab106386) at 2 µg/ml

    Lane 1 : Human uterus tissue lysate
    Lane 2 : Human uterus tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 58 kDa
  • Immunohistochemistry of FTO in Mouse brain tissue with ab106386 at 2.5 µg/ml.
  • Immunofluorescence of FTO in Mouse Brain cells using ab106386 at 20 ug/ml.

Anti-FTO antibody (ab106386) 使用論文

ab106386 has not yet been referenced specifically in any publications.

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