製品の概要
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製品名Anti-FSH Receptor antibody
FSH Receptor 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to FSH Receptor
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由来種Rabbit
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アプリケーション適用あり: ELISA, IHC-P, ICC/IFmore details
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種交差性交差種: Human
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免疫原
Synthetic peptide corresponding to Human FSH Receptor aa 278-327 (internal sequence).
Database link: P23945 -
ポジティブ･コントロール
- Human Ovary tissue; MCF7 cells.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
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バッファーpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 0.88% Sodium chloride
Note: PBS (without Mg2+, Ca2+) -
Concentration information loading... -
精製度Protein A purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab113421 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ELISA | 1/1000. | |
| IHC-P | Use a concentration of 10 µg/ml. | |
| ICC/IF | 1/100 - 1/500. |
ターゲット情報
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機能Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
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組織特異性Sertoli cells and ovarian granulosa cells.
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関連疾患Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. -
配列類似性Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain. -
翻訳後修飾N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.
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細胞内局在Cell membrane.
- Information by UniProt
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参照データベース
- Entrez Gene: 2492 Human
- Omim: 136435 Human
- SwissProt: P23945 Human
- Unigene: 1428 Human
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別名
- Follicle stimulating hormone receptor antibody
- Follicle stimulating hormone receptor isoform 1 antibody
- Follicle-stimulating hormone receptor antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FSH Receptor antibody (ab113421)ab113421 at 10 µg/ml staining FSH Receptor in Human ovary by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. -
Immunocytochemistry/ Immunofluorescence - FSH Receptor antibody (ab113421)Immunofluorescence analysis of MCF7 cells, using ab113421 at 1/100 dilution. The image on the right is treated with the synthesized peptide.
参考文献
ab113421 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"