製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to FRMD7
  • アプリケーション
    適用あり: ICC/IF, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment corresponding to amino acids 504-653 of Human FRMD7 (Q6ZUT3).

  • ポジティブ・コントロール
    • Human stomach tissue

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab121119 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval.

ターゲット情報

  • 機能
    Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability.
  • 組織特異性
    Expressed in liver, kidney, pancreas and at low levels in brain and heart. Expressed in embryonic brain and developing neural retina.
  • 関連疾患
    Defects in FRMD7 are the cause of nystagmus congenital X-linked type 1 (NYS1) [MIM:310700]. NYS1 is a condition defined as conjugated, spontaneous and involuntary ocular oscillations that appear at birth or during the first three months of life. Other associated features may include mildly decreased visual acuity, strabismus, astigmatism, and occasionally head nodding.
  • 配列類似性
    Contains 1 FERM domain.
  • 発生段階
    In 37 day post-ovulation (dpo) embryos, expression is found in the mid- and hindbrain, regions known to be involved in motor control of eye movement, and in the ventricular zone of the forebrain. In 56 dpo embryos, expressed in the ventricular layer of the forebrain, midbrain, cerebellar primordium, spinal cord and the developing neural retina. In later development, highly expressed in postmitotic cells within the developing subplate and cortical plate.
  • 細胞内局在
    Cell projection. Cell projection > growth cone. In undifferentiated neurons, located in the actin-rich regions of the cell body. In differentiated neurons, located in the actin-rich regions of the cell body and primary neurite processes but is almost absent from secondary extensions arising from the primary neurite. Also found at the actin-rich distal end of growth cones.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FERM domain-containing protein 7 antibody
    • FRMD7 antibody
    • FRMD7_HUMAN antibody

Anti-FRMD7 antibody 画像

  • Immunofluorescent staining of Human cell line A-431 shows positivity in nucleus but not nucleoli and cytoplasm. Recommended concentration of ab121119 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab121119 at 1/250 dilution staining FRMD7 in Paraffin-emebedded Human stomach tissue by Immunohistochemistry. Note: strong cytoplasmic positivity in glandular cells.

Anti-FRMD7 antibody (ab121119) 使用論文

ab121119 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab121119.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録