製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to Frizzled 9
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog
  • 免疫原

    Synthetic peptide:

    C-TKTDPSLENPTH

    , corresponding to C terminal amino acids 579-590 of Human Frizzled 9

  • ポジティブ・コントロール
    • Formalin Fixed, Paraffin Embedded Human Testis Formalin Fixed, Paraffin Embedded Human Thyroid

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能
    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
  • 組織特異性
    Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney.
  • 配列類似性
    Belongs to the G-protein coupled receptor Fz/Smo family.
    Contains 1 FZ (frizzled) domain.
  • ドメイン
    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
    The FZ domain is involved in binding with Wnt ligands.
  • 細胞内局在
    Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD 349 antibody
    • CD 349 antigen antibody
    • CD349 antibody
    • Frizzled Drosophila homolog of 3 antibody
    • Frizzled homolog 9 (Drosophila) antibody
    • Frizzled homolog 9 antibody
    • Frizzled-9 antibody
    • Fz 9 antibody
    • Fz-9 antibody
    • FZD 3 antibody
    • Fzd 9 antibody
    • FZD3 antibody
    • FZD3-PEN antibody
    • FZD9 antibody
    • FZD9_HUMAN antibody
    • FzE6 antibody
    • hFz9 antibody
    • mfz9 antibody
    • Xfz9 antibody
    see all

画像

  • ab110886, at 5 µg/ml, staining Frizzled 9 in Formalin Fixed, Paraffin Embedded Human testis tissue by Immunohistochemistry.
  • ab110886, at 5 µg/ml, staining Frizzled 9 in Formalin Fixed, Paraffin Embedded Human thyroid tissue by Immunohistochemistry.

プロトコール

参考文献

ab110886 has not yet been referenced specifically in any publications.

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