製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to Frizzled 7
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Chicken, Cow, Dog, Xenopus laevis, Chimpanzee, Rhesus monkey
  • 免疫原

    Synthetic peptide:

    C-RFYHRLSHSSKGET

    , corresponding to C terminal amino acids 559-572 of Human Frizzled 7 (NP_003498.1).

  • ポジティブ・コントロール
    • HEK293 and HepG2 cell lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab77379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報
    Peptide ELISA: Antibody detection limit dilution 1/64000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 64 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
    • 組織特異性
      High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.
    • 配列類似性
      Belongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • ドメイン
      Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.
      The FZ domain is involved in binding with Wnt ligands.
    • 細胞内局在
      Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Frizzled 7, seven transmembrane spanning receptor antibody
      • frizzled class receptor 7 antibody
      • Frizzled drosophila homolog of 7 antibody
      • Frizzled family receptor 7 antibody
      • Frizzled homolog 7 antibody
      • Frizzled-7 antibody
      • Frizzled7 antibody
      • Fz 7 antibody
      • Fz-7 antibody
      • Fz7 antibody
      • FZD 7 antibody
      • FZD7 antibody
      • FZD7_HUMAN antibody
      • FzE 3 antibody
      • FzE3 antibody
      • hFz 7 antibody
      • hFz7 antibody
      • Homolog of Drosophila Frizzled 7 antibody
      • OTTHUMP00000163742 antibody
      see all

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    参考文献

    ab77379 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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