製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Frizzled 6
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within internal amino acids 539-588 (HKKKHYKPSS HKLKVISKSM GTSTGATANH GTSAVAITSH DYLGQETLTE) of Human Frizzled 6 (NP_003497).

  • ポジティブ・コントロール
    • ACHN cell lysate.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab98933 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 79 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear.
  • 組織特異性
    Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.
  • 関連疾患
    Nail disorder, non-syndromic congenital, 10
    Rare non-synonymous variants in FZD6 may contribute to neural tube defects, congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy.
  • 配列類似性
    Belongs to the G-protein coupled receptor Fz/Smo family.
    Contains 1 FZ (frizzled) domain.
  • ドメイン
    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
    The FZ domain is involved in binding with Wnt ligands.
  • 翻訳後修飾
    Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  • 細胞内局在
    Membrane. Cell membrane. Cell surface. Apical cell membrane. Cytoplasmic vesicle membrane. Colocalizes with FZD3 at the apical face of cells (By similarity).
  • Information by UniProt
  • 参照データベース
  • 別名
    • Frizzled 6 seven transmembrane spanning receptor antibody
    • Frizzled drosophila homolog of 6 antibody
    • Frizzled family receptor 6 antibody
    • Frizzled homolog 6 (Drosophila) antibody
    • Frizzled homolog 6 antibody
    • Frizzled-6 antibody
    • Frizzled6 antibody
    • Fz 6 antibody
    • Fz-6 antibody
    • Fz6 antibody
    • FZD 6 antibody
    • Fzd6 antibody
    • FZD6_HUMAN antibody
    • Hfz 6 antibody
    • hFz6 antibody
    • NDNC10 antibody
    see all

画像

  • Anti-Frizzled 6 antibody (ab98933) at 1 µg/ml + ACHN cell lysate at 10 µg

    Predicted band size : 79 kDa

プロトコール

参考文献

ab98933 has not yet been referenced specifically in any publications.

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