製品の概要

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab58145 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
    • 組織特異性Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.
    • 配列類似性Belongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • ドメインLys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.
      The FZ domain is involved in binding with Wnt ligands.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Frizzled homolog 2 antibody
      • Frizzled-2 antibody
      • Frizzled2 antibody
      • Fz 2 antibody
      • Fz-2 antibody
      • Fz2 antibody
      • FZD 2 antibody
      • FZD2 antibody
      • FZD2_HUMAN antibody
      • FzE 2 antibody
      • FzE2 antibody
      • hFz 2 antibody
      • hFz2 antibody
      • Mfz10 antibody
      see all

    Anti-Frizzled 2 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab58145 Frizzled 2 antibody at 1ug/ml. Predicted band size of immunogen is 32 kDa

    Anti-Frizzled 2 antibody (ab58145) 使用論文

    This product has been referenced in:
    • Ohba S  et al. Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes. Osteoarthritis Cartilage 18:1620-9 (2010). WB ; Human . Read more (PubMed: 20868760) »

    See 1 Publication for this product

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    There are currently no Abreviews or Questions for ab58145.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"