製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Frequenin
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Rat
    交差が予測される動物種: Mouse, Chicken, Cow, Human, Xenopus laevis, Drosophila melanogaster
  • 免疫原

    Synthetic peptide corresponding to Rat Frequenin aa 161-190.
    Sequence:

    DGKLTLQEFQEGSKADPSIVQALSLYDGLV

  • ポジティブ・コントロール
    • Rat brain extract.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    Preservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 99% PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 一次抗体 備考
    The neuronal calcium sensor (NCS) proteins are bind calcium through EF-hand motifs and are predominantly expressed in neurons. Photoreceptor cells express type A sensors and include the proteins recoverin, S-modulin, and visinin. Type B receptors are expressed in neurons and include NCS1 and the Drosophila homolog frequenin, and VILIP. NCS1 has been shown to regulate neurosecretion in a calcium-dependent manner, potentiates nitric oxide synthase activity, and can activate calcineurin and 3'-5' nucleotide phosphodiesterase.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab5807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 20 kDa (predicted molecular weight: 25 kDa).

ターゲット情報

  • 機能
    Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.
  • 配列類似性
    Belongs to the recoverin family.
    Contains 4 EF-hand domains.
  • 細胞内局在
    Golgi apparatus > Golgi stack membrane. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cytoplasm > perinuclear region. Cell membrane. Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Flup antibody
    • Freq antibody
    • frequenin (Drosophila) homolog antibody
    • Frequenin homolog antibody
    • Frequenin-like protein antibody
    • Frequenin-like ubiquitous protein antibody
    • NCS-1 antibody
    • ncs1 antibody
    • NCS1_HUMAN antibody
    • Neuronal calcium sensor 1 antibody
    see all

プロトコール

参考文献

ab5807 has not yet been referenced specifically in any publications.

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