製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to FREM2
  • アプリケーション
    適用あり: WB, ELISA, IHC-P, ICCmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to 19 internal sequence amino acids of Human FREM2.

  • ポジティブ・コントロール
    • Human Breast and Human Kidney tissues.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab117612 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 351 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.
ICC Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion.
  • 関連疾患
    Defects in FREM2 are a cause of Fraser syndrome (FRASS) [MIM:219000]. Fraser syndrome is a multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects.
  • 配列類似性
    Belongs to the FRAS1 family.
    Contains 5 Calx-beta domains.
    Contains 12 CSPG (NG2) repeats.
  • ドメイン
    The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.
  • 細胞内局在
    Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DKFZp781I048 antibody
    • ECM3 homolog antibody
    • FRAS1-related extracellular matrix protein 2 antibody
    • FREM 2 antibody
    • Frem2 antibody
    • FREM2_HUMAN antibody
    • KIAA1074 antibody
    see all

画像

  • ab117612, at 5 µg/ml, staining FREM2 in Formalin-fixed, Paraffin-embedded Human breast tissue by Immunohistochemistry.
  • ab117612, at 5 µg/ml, staining FREM2 in Formalin-fixed, Paraffin-embedded Human Kidney tissue by Immunohistochemistry.

参考文献

ab117612 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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