製品の概要

  • 製品名Anti-FPR1 antibody
    FPR1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FPR1
  • 特異性ab113531 detects endogenous levels of total FPR1 protein.
  • アプリケーション適用あり: WB, ELISA, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, from an internal region of Human FPR1.

  • ポジティブ・コントロール
    • Human spleen tissue; K562 cell extracts; MCF7 cells.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab113531 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 38 kDa.
ELISA 1/1000.
IHC-P Use a concentration of 5 µg/ml.
ICC/IF 1/100 - 1/500.

ターゲット情報

  • 機能High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
  • 組織特異性Neutrophils.
  • 配列類似性Belongs to the G-protein coupled receptor 1 family.
  • 翻訳後修飾Phosphorylated; which is necessary for desensitization.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • fMet Leu Phe receptor antibody
    • fMet-Leu-Phe receptor antibody
    • FMLP antibody
    • fMLP receptor antibody
    • FMLPR antibody
    • Formyl peptide receptor 1 antibody
    • FPR 1 antibody
    • FPR antibody
    • FPR receptor antibody
    • FPR1 antibody
    • FPR1_HUMAN antibody
    • N formyl peptide chemoattractant receptor antibody
    • N formyl peptide receptor antibody
    • N formylpeptide chemoattractant receptor antibody
    • N-formyl peptide receptor antibody
    • N-formylpeptide chemoattractant receptor antibody
    see all

Anti-FPR1 antibody 画像

  • All lanes : Anti-FPR1 antibody (ab113531) at 1/500 dilution

    Lane 1 : K562 cell extract
    Lane 2 : K562 cell extract with immunizing peptide


    Predicted band size : 38 kDa
  • ab113531 at 5ug/ml staining FPR1 in Formalin-Fixed, Paraffin-Embedded Human spleen tissue by Immunohistochemistry.
  • ab113531 at a 1/100 dilution staining FPR1 in Human MCF7 cells by Immunofluorescence. The cells on the right were incubated with the immunizing peptide.

Anti-FPR1 antibody (ab113531) 使用論文

This product has been referenced in:
  • Machado ID  et al. Alterations in the profile of blood neutrophil membrane receptors caused by in vivo adrenocorticotrophic hormone actions. Am J Physiol Endocrinol Metab 307:E754-63 (2014). Read more (PubMed: 25184992) »

See 1 Publication for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (Frozen sections)
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 22°C
Sample Human Tissue sections (skin)
Specification skin
Permeabilization No
Fixative Acetone
Username

Abcam user community

Verified customer

投稿 Jul 19 2013

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this...

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Thank you for your reply.

I have confirmed with the laboratory that we have not tested the antibody for cross-reactivity with FPR2. However, I compared the sequence of the peptide used to generate ab113531 to the corresponding region of FPR2...

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Thank you for contacting Abcam regarding ab113531.

Regarding the molecular weight of the FPR1 protein, the predicted molecular weight is indeed 38kDa, however this protein is also subject to several posttranslational modifications, including...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"