Anti-FOXP3 抗体 (ab75763)
Key features and details
- Rabbit polyclonal to FOXP3
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Rat
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
-
製品名
Anti-FOXP3 antibody
FOXP3 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to FOXP3 -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Mouse, Rat
交差が予測される動物種: Cow, Cat, Human, Pig, Monkey, Cynomolgus monkey, Rhesus monkey, Deer -
免疫原
Synthetic peptide corresponding to Mouse FOXP3 aa 200-300. The peptide was post synthetically modified to achieve desired antigenicity before coupling to a carrier protein.
Database link: Q99JB6 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.02% Sodium azide -
Concentration information loading...
-
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab75763の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
1/500. Detects a band of approximately 52-55, 25-29 kDa (predicted molecular weight: 47 kDa).
|
|
IHC-P | (1) |
1/100.
|
特記事項 |
---|
WB
1/500. Detects a band of approximately 52-55, 25-29 kDa (predicted molecular weight: 47 kDa). |
IHC-P
1/100. |
ターゲット情報
-
機能
Probable transcription factor. Plays a critical role in the control of immune response. -
関連疾患
Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy. -
配列類似性
Contains 1 C2H2-type zinc finger.
Contains 1 fork-head DNA-binding domain. -
細胞内局在
Nucleus. - Information by UniProt
-
参照データベース
- Entrez Gene: 506053 Cow
- Entrez Gene: 102120882 Cynomolgus monkey
- Entrez Gene: 50943 Human
- Entrez Gene: 20371 Mouse
- Entrez Gene: 444998 Pig
- Entrez Gene: 317382 Rat
- Omim: 300292 Human
- SwissProt: Q6U8D7 Cynomolgus monkey
see all -
別名
- AIID antibody
- DIETER antibody
- Forkhead box P3 antibody
see all
画像
-
Immunofluorescence of tumors from mice treated with MN-siPDL1 and gemcitabine. There was evidence of an increase in cell-mediated cytotoxicity, as evidenced by a decrease in the infiltration by immunosuppressive Foxp3 + regulatory T (Treg) cells detected using ab75763.
This image has been cropped from the origanal figure.
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of Mouse kidney tissue staining FOXP3 using ab75763 at 1/100. DAB staining (brown) Hematoxylin QS counterstain (blue).
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of Mouse kidney tissue staining FOXP3 using ab75763 at 1/100. DAB staining (brown) Hematoxylin QS counterstain (blue).
-
All lanes : Anti-FOXP3 antibody (ab75763) at 1/500 dilution
Lane 1 : rat kidney lysate
Lane 2 : rat cerebral cortex lysate
Predicted band size: 47 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of Rat kidney tissue staining FOXP3 using ab75763 at 1/100. DAB staining (brown) Hematoxylin QS counterstain (blue).
プロトコール
データシートおよび資料
-
Datasheet download
参考文献 (7)
ab75763 は 7 報の論文で使用されています。
- Fang Z et al. CS12192, a Novel JAK3/JAK1/TBK1 Inhibitor, Synergistically Enhances the Anti-Inflammation Effect of Methotrexate in a Rat Model of Rheumatoid Arthritis. Int J Mol Sci 23:N/A (2022). PubMed: 36362183
- Zhou J et al. Taurine promotes the production of CD4+CD25+FOXP3+ Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model. Allergy Asthma Clin Immunol 17:59 (2021). PubMed: 34147127
- Zhang Y et al. Hydrogel-load exosomes derived from dendritic cells improve cardiac function via Treg cells and the polarization of macrophages following myocardial infarction. J Nanobiotechnology 19:271 (2021). PubMed: 34496871
- Li W et al. Lymphatic drainage from bronchus-associated lymphoid tissue in tolerant lung allografts promotes peripheral tolerance. J Clin Invest 130:6718-6727 (2020). PubMed: 33196461
- Yoo B et al. RNAi-Mediated PD-L1 Inhibition for Pancreatic Cancer Immunotherapy. Sci Rep 9:4712 (2019). IHC-P ; Mouse . PubMed: 30886310
- Ma Y et al. Hydroxyl safflower yellow A regulates the tumor immune microenvironment to produce an anticancer effect in a mouse model of hepatocellular carcinoma. Oncol Lett 17:3503-3510 (2019). Flow Cyt . PubMed: 30867790
- Lockett NN et al. Expression of regulatory T cell (Treg) activation markers in endometrial tissues from early and late pregnancy in the feline immunodeficiency virus (FIV)-infected cat. Placenta 31:796-802 (2010). IHC-FoFr ; Cat . PubMed: 20674972