製品の概要

  • 製品名Anti-FOXE3 antibody
    FOXE3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FOXE3
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from an internal region of Human FOXE3

  • ポジティブ・コントロール
    • extracts from 562 cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab72596 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 33 kDa (predicted molecular weight: 33 kDa).
ELISA 1/5000.

ターゲット情報

  • 関連疾患Defects in FOXE3 are a cause of anterior segment mesenchymal dysgenesis (ASMD) [MIM:107250]; also known as anterior segment ocular dysgenesis (ASOD). ASMD consists of a range of developmental defects in structures at the front of the eye, resulting from abnormal migration or differentiation of the neural crest derived mesenchymal cells that give rise to the cornea, iris, and other components of the anterior chamber during eye development. Mature anterior segment anomalies are associated with an increased risk of glaucoma and corneal opacity. Conditions falling within the phenotypic spectrum include aniridia, posterior embryotoxon, Axenfeld anomaly, Reiger anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis.
    Defects in FOXE3 are a cause of congenital primary aphakia (CPA) [MIM:610256]. Aphakia is a rare congenital eye disorder in which the lens is missing. It has been histologically subdivided into primary and secondary forms, in accordance with the severity of defects of the ocular tissues, whose development requires the initial presence of a lens. CPA results from an early developmental arrest, around the 4th-5th week of gestation in humans, that prevents the formation of any lens structure and leads to severe secondary ocular defects, including a complete aplasia of the anterior segment of the eye. In contrast, in secondary aphakic eyes, lens induction has occurred, and the lens vesicle has developed to some degree but finally has progressively resorbed perinatally, leading, therefore, to less-severe ocular defects.
  • 配列類似性Contains 1 fork-head DNA-binding domain.
  • 発生段階Expressed in the lens during embryonic development. Predominantly expressed in the anterior lens epithelium but with some expression posteriorly. Not expressed in brain in embryos.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Drosphilia Forkhead Homolog Like 12 antibody
    • FKHL 12 antibody
    • FKHL12 antibody
    • Forkhead Box E3 antibody
    • Forkhead box protein E3 antibody
    • Forkhead Related Activator 8 antibody
    • Forkhead related protein FKHL12 antibody
    • Forkhead-related protein FKHL12 antibody
    • Forkhead-related transcription factor 8 antibody
    • Foxe3 antibody
    • FOXE3 forkhead box E3 antibody
    • FOXE3_HUMAN antibody
    • FREAC 8 antibody
    • FREAC-8 antibody
    • FREAC8 antibody
    see all

Anti-FOXE3 antibody 画像

  • All lanes : Anti-FOXE3 antibody (ab72596) at 1/500 dilution

    Lane 1 : extracts from 562 cells
    Lane 2 : extracts from 562 cells, with 10 ug of the immunising peptide

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 33 kDa
    Observed band size : 33 kDa

Anti-FOXE3 antibody (ab72596) 使用論文

ab72596 has not yet been referenced specifically in any publications.

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Thank you for contacting us. I have had an opportunity to go through a number of our antibodies and discuss your needs with the laboratory. Unfortunately, the difference in homology between these Xenopus targets and the peptides from which each immun...

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