製品の概要

  • 製品名Anti-FOXC1 antibody
    FOXC1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to FOXC1
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Xenopus laevis, Zebrafish
  • 免疫原

    Synthetic peptide:

    RTSGAFVYDCSKF

    , corresponding to C terminal amino acids 541-553 of Human FOXC1 (NP_001444.1).

  • ポジティブ・コントロール
    • WB: Human bone marrow lysate IHC-P: Human kidney tissue

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab97742 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 56 kDa.
IHC-P Use a concentration of 3 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.

ターゲット情報

  • 機能Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees.
  • 組織特異性Expressed in all tissues and cell lines examined.
  • 関連疾患Defects in FOXC1 are the cause of Axenfeld-Rieger syndrome type 3 (RIEG3) [MIM:602482]; also known as Axenfeld-Rieger syndrome (ARS) or Axenfeld syndrome or Axenfeld anomaly. It is characterized by posterior corneal embryotoxon, prominent Schwalbe line and iris adhesion to the Schwalbe line. Other features may be hypertelorism (wide spacing of the eyes), hypoplasia of the malar bones, congenital absence of some teeth and mental retardation. When associated with tooth anomalies, the disorder is known as Rieger syndrome. Glaucoma is a progressive blinding condition that occurs in approximately half of patients with Axenfeld-Rieger malformations.
    Defects in FOXC1 are the cause of iridogoniodysgenesis anomaly (IGDA) [MIM:601631]. IGDA is an autosomal dominant phenotype characterized by iris hypoplasia, goniodysgenesis, and juvenile glaucoma.
    Defects in FOXC1 are a cause of Peters anomaly (PAN) [MIM:604229]. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.
  • 配列類似性Contains 1 fork-head DNA-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ARA antibody
    • FKH L7 antibody
    • FKHL 7 antibody
    • FKHL7 antibody
    • Forkhead (Drosophila) like 7 antibody
    • Forkhead box C1 antibody
    • Forkhead box protein C1 antibody
    • Forkhead drosophila homolog like 7 antibody
    • Forkhead like 7 antibody
    • Forkhead related activator 3 antibody
    • Forkhead related protein FKHL7 antibody
    • Forkhead related transcription factor 3 antibody
    • Forkhead-related protein FKHL7 antibody
    • Forkhead-related transcription factor 3 antibody
    • FOX C1 antibody
    • FOXC 1 antibody
    • Foxc1 antibody
    • FOXC1_HUMAN antibody
    • FREAC 3 antibody
    • FREAC-3 antibody
    • FREAC3 antibody
    • IGDA antibody
    • IHG 1 antibody
    • IHG1 antibody
    • IRID 1 antibody
    • IRID1 antibody
    • Iridogoniodysgenesis type 1 antibody
    • Myeloid factor delta antibody
    see all

Anti-FOXC1 antibody 画像

  • Anti-FOXC1 antibody (ab97742) at 0.5 µg/ml + Human bone marrow lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 56 kDa


    Exposure time : 1 hour
  • Immunohistochemical analysis of FOXC1 in paraffin embedded Human kidney tissue, using ab97742 at 3 µg/ml.
    Microwaved antigen retrieval with Tris/EDTA buffer pH9 and HRP staining were used.
    The image shows nuclear staining of some cells in the glomeruli.

Anti-FOXC1 antibody (ab97742) 使用論文

ab97742 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab97742.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"