Anti-Folate Binding Protein 抗体 (HRP) - Azide free (ab20572)

製品の概要

  • 製品名
    Anti-Folate Binding Protein antibody (HRP) - Azide free
    Folate Binding Protein 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Folate Binding Protein - Azide free (HRP)
  • 標識
    HRP
  • 特異性
    This antibody targets both purified and partially purified Folate Binding Protein from bovine milk.
  • アプリケーション
    適用あり: WB, Dot blot, ELISA, IHC-P, IHC-Fr, Immunomicroscopymore details
  • 種交差性
    交差種: Cow
  • 免疫原

    Folate Binding Protein (bovine milk).

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C.
  • バッファー
    Preservative: 0.01% Gentamicin Sulfate
    Constituents: PBS, 10mg/ml Polyethylene glycol (PEG 8000). pH 7.2
  • Concentration information loading...
  • 特記事項(精製)
    Purified from monospecific antiserum by delipidation, fractionation and ion exchange chromatography.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab20572 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.
Dot blot Use at an assay dependent dilution.
ELISA 1/2000 - 1/12000.
IHC-P 1/100 - 1/200.
IHC-Fr 1/100 - 1/200.
Immunomicroscopy Use at an assay dependent dilution.

ターゲット情報

  • 機能
    Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
  • 組織特異性
    Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.
  • 関連疾患
    Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function.
  • 配列類似性
    Belongs to the folate receptor family.
  • 翻訳後修飾
    Eight disulfide bonds are present.
    The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
  • 細胞内局在
    Cell membrane. Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • adult antibody
    • Adult folate binding protein antibody
    • Adult folate-binding protein antibody
    • FBP antibody
    • Folate Receptor 1 Adult antibody
    • Folate receptor 1 antibody
    • Folate Receptor 1 Precursor antibody
    • Folate receptor adult antibody
    • Folate receptor alpha antibody
    • Folate receptor antibody
    • FOLR antibody
    • FOLR1 antibody
    • FOLR1_HUMAN antibody
    • FR alpha antibody
    • FR-alpha antibody
    • FRalpha antibody
    • KB cells FBP antibody
    • MOV18 antibody
    • Ovarian cancer associated antigen antibody
    • Ovarian tumor associated antigen antibody
    • Ovarian tumor associated antigen MOv18 antibody
    • Ovarian tumor-associated antigen MOv18 antibody
    see all

画像

  • Immunohistochemical analysis of Human clear cell ovarian carcinoma tissue, staining Folate Binding Protein with ab20572 at 1/200 dilution.

参考文献

This product has been referenced in:
  • Siu MK  et al. Paradoxical impact of two folate receptors, FRa and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome. PLoS One 7:e47201 (2012). IHC-P . Read more (PubMed: 23144806) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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