製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to FOG2
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C-terminal amino acids 882-911 of Human FOG2 (NP_036214.20.

  • ポジティブ・コントロール
    • Hela cell line lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123879 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 128 kDa.

ターゲット情報

  • 機能
    Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.
  • 組織特異性
    Widely expressed at low level.
  • 関連疾患
    Defects in ZFPM2 may be a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
    Defects in ZFPM2 are the cause of diaphragmatic hernia 3 (DIH3) [MIM:610187]; a form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension.
  • 配列類似性
    Belongs to the FOG (Friend of GATA) family.
    Contains 3 C2H2-type zinc fingers.
    Contains 5 C2HC-type zinc fingers.
  • ドメイン
    The CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FOG-2 antibody
    • FOG2_HUMAN antibody
    • Friend of GATA 2 antibody
    • Friend of GATA protein 2 antibody
    • Friend of GATA2 antibody
    • hFOG-2 antibody
    • ZFPM2 antibody
    • Zinc finger protein 89B antibody
    • Zinc finger protein M2 antibody
    • Zinc finger protein multitype 2 antibody
    • Zinc finger protein ZFPM2 antibody
    see all

画像

  • Anti-FOG2 antibody (ab123879) at 1/100 dilution + Hela cell line lysate at 35 µg

    Predicted band size : 128 kDa

プロトコール

参考文献

ab123879 has not yet been referenced specifically in any publications.

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