製品の概要

  • 製品名Anti-FOG2 antibody
    FOG2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FOG2
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 745-874 of Human FOG2.

  • ポジティブ・コントロール
    • Human placenta tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab121212 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.
  • 組織特異性Widely expressed at low level.
  • 関連疾患Defects in ZFPM2 may be a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
    Defects in ZFPM2 are the cause of diaphragmatic hernia 3 (DIH3) [MIM:610187]; a form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension.
  • 配列類似性Belongs to the FOG (Friend of GATA) family.
    Contains 3 C2H2-type zinc fingers.
    Contains 5 C2HC-type zinc fingers.
  • ドメインThe CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FOG-2 antibody
    • FOG2_HUMAN antibody
    • Friend of GATA 2 antibody
    • Friend of GATA protein 2 antibody
    • Friend of GATA2 antibody
    • hFOG-2 antibody
    • ZFPM2 antibody
    • Zinc finger protein 89B antibody
    • Zinc finger protein M2 antibody
    • Zinc finger protein multitype 2 antibody
    • Zinc finger protein ZFPM2 antibody
    see all

Anti-FOG2 antibody 画像

  • ab121212 at 1/25 dilution staining FOG2 in Paraffin-embedded Human Placenta tissue by Immunohistochemistry.

Anti-FOG2 antibody (ab121212) 使用論文

ab121212 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Frozen sections)
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 10% · Temperature: RT°C
Sample Rhesus monkey Tissue sections (Brain)
Specification Brain
Permeabilization No
Fixative Paraformaldehyde
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投稿 Sep 02 2014

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"