製品の概要

  • 製品名Anti-FLVCR antibody
    FLVCR 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to FLVCR
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: MARPDDEEGA AVAPGHPLAK GYLPLPRGAP VGKESVELQN GPKAGTFPVN GAPRDSLAAA SGVLGGPQTP LAPEEETQAR LLP, corresponding to amino acids 1-84 of Human FLVCR

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab57317 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro.
    • 組織特異性Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney.
    • 関連疾患Defects in FLVCR1 are the cause of posterior column ataxia with retinitis pigmentosa (PCARP) [MIM:609033]. A neurodegenerative syndrome beginning in infancy with areflexia and retinitis pigmentosa. Nyctalopia (night blindness) and peripheral visual field loss are usually evident during late childhood or teenage years, with subsequent progressive constriction of the visual fields and loss of central retinal function over time. A sensory ataxia caused by degeneration of the posterior columns of the spinal cord results in a loss of proprioceptive sensation that is clinically evident in the second decade of life and gradually progresses. Scoliosis, camptodactyly, achalasia, gastrointestinal dysmotility, and a sensory peripheral neuropathy are variable features of the disease. Affected individuals have no clinical or radiological evidence of cerebral or cerebellar involvement. Note=Defective neuronal heme transmembrane export due to FLVCR1 mutations may abrogate the neuroprotective effects of neuroglobin and initiate an apoptotic cascade that results in the selective degeneration of photoreceptors in the neurosensory retina and sensory neurons in the posterior spinal cord.
    • 配列類似性Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
    • 発生段階Down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization. Abundant in fetal liver.
    • 細胞内局在Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Feline leukemia virus subgroup C cellular receptor antibody
      • Feline leukemia virus subgroup C receptor antibody
      • Feline leukemia virus subgroup C receptor related protein 1 antibody
      • Feline leukemia virus subgroup C receptor-related protein 1 antibody
      • FLVC1_HUMAN antibody
      • FLVCR 1 antibody
      • FLVCR protein antibody
      • FLVCR1 antibody
      • hFLVCR antibody
      see all

    Anti-FLVCR antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab57317 FLVCR antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    Anti-FLVCR antibody (ab57317) 使用論文

    ab57317 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"