製品の概要

  • 製品名Anti-FLVCR antibody
    FLVCR 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FLVCR
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 223-272 (GPKEVSTACA TAVLGNQLGT AVGFLLPPVL VPALGTQNST GLLAHTQNNT) of Mouse FLVCR (NP_001074728).

  • ポジティブ・コントロール
    • Mouse brain lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro.
  • 組織特異性Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney.
  • 関連疾患Defects in FLVCR1 are the cause of posterior column ataxia with retinitis pigmentosa (PCARP) [MIM:609033]. A neurodegenerative syndrome beginning in infancy with areflexia and retinitis pigmentosa. Nyctalopia (night blindness) and peripheral visual field loss are usually evident during late childhood or teenage years, with subsequent progressive constriction of the visual fields and loss of central retinal function over time. A sensory ataxia caused by degeneration of the posterior columns of the spinal cord results in a loss of proprioceptive sensation that is clinically evident in the second decade of life and gradually progresses. Scoliosis, camptodactyly, achalasia, gastrointestinal dysmotility, and a sensory peripheral neuropathy are variable features of the disease. Affected individuals have no clinical or radiological evidence of cerebral or cerebellar involvement. Note=Defective neuronal heme transmembrane export due to FLVCR1 mutations may abrogate the neuroprotective effects of neuroglobin and initiate an apoptotic cascade that results in the selective degeneration of photoreceptors in the neurosensory retina and sensory neurons in the posterior spinal cord.
  • 配列類似性Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
  • 発生段階Down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization. Abundant in fetal liver.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Feline leukemia virus subgroup C cellular receptor antibody
    • Feline leukemia virus subgroup C receptor antibody
    • Feline leukemia virus subgroup C receptor related protein 1 antibody
    • Feline leukemia virus subgroup C receptor-related protein 1 antibody
    • FLVC1_HUMAN antibody
    • FLVCR 1 antibody
    • FLVCR protein antibody
    • FLVCR1 antibody
    • hFLVCR antibody
    see all

Anti-FLVCR antibody 画像

  • Anti-FLVCR antibody (ab115865) at 1 µg/ml + Mouse brain lysate at 10 µg

    Predicted band size : 60 kDa

Anti-FLVCR antibody (ab115865) 使用論文

ab115865 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"