membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)
機能May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
組織特異性In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes.
配列類似性Belongs to the band 7/mec-2 family. Flotillin subfamily.
細胞内局在Cell membrane. Membrane > caveola. Endosome. Membrane-associated protein of caveolae.