製品の概要

  • 製品名Anti-FLJ22167 antibody
    FLJ22167 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FLJ22167
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    A region within synthetic peptide: FNSGFWLKRS SYEEQPTVRF QHQVLLVALL GPESDGFLAW STFPAFNRLQ, corresponding to amino acids 73-122 of Human FLJ22167

  • ポジティブ・コントロール
    • Human kidney tissue and HepG2 cell lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab62475 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay: 1/312500.

IHC-P Use a concentration of 4 - 8 µg/ml.

ターゲット情報

  • 機能Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
  • 関連疾患Defects in TMEM231 are the cause of Joubert syndrome 20 (JBTS20) [MIM:614970]. A disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease.
  • 配列類似性Belongs to the TMEM231 family.
  • 細胞内局在Cell projection > cilium membrane. Localizes to the transition zone of primary cilia; SEPT2 is required for localization to the transition zone.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ALYE870 antibody
    • CDNA: FLJ22167 fis, clone HRC00584 antibody
    • hCG 2043031 antibody
    • HCG2043031, isoform CRA a antibody
    • hypothetical protein LOC79583 antibody
    • JBTS20 antibody
    • PRO1886 antibody
    • Putative uncharacterized protein FLJ22167 antibody
    • Q9H6L2 antibody
    • TM231_HUMAN antibody
    • Tmem231 antibody
    • Transmembrane protein 231 antibody
    • UNQ870/PRO1886 antibody
    • UPF0513 membrane protein antibody
    see all

Anti-FLJ22167 antibody 画像

  • All lanes : Anti-FLJ22167 antibody (ab62475) at 1.25 µg/ml

    Lane 1 : marker
    Lane 2 : HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 36 kDa
    Observed band size : 36 kDa
    Additional bands at : 75 kDa. We are unsure as to the identity of these extra bands.
    Gel concentration 12%
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling FLJ22167 with ab62475 at 4-8µg/ml. Arrows indicate positively labelled renal tubule epithelial cells. Magnification: 400X.

Anti-FLJ22167 antibody (ab62475) 使用論文

ab62475 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"