製品の概要

  • 製品名Anti-Flightless I antibody
    Flightless I 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Flightless I
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 425 - 475 of Human Flightless I (NP_002009.1)

  • ポジティブ・コントロール
    • Breast carcinoma, colon carcinoma, ovarian carcinoma, prostate carcinoma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84778 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer may enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration.
    • 組織特異性Strongest expression in skeletal muscle with high expression also in the heart and lung.
    • 関連疾患Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS) [MIM:182290]. It is a contiguous gene deletion syndrome involving developmental abnormalities and mental retardation. The spectrum of clinical findings includes short stature, brachydactyly, developmental delay, dysmorphic features, sleep disturbances, and behavioral problems.
    • 配列類似性Contains 5 gelsolin-like repeats.
      Contains 15 LRR (leucine-rich) repeats.
    • 細胞内局在Nucleus. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Colocalizes to actin-rich structures in blastocysts and, together with HRAS1, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Fli 1 antibody
      • FLI antibody
      • Fli1 antibody
      • Flightless 1 antibody
      • Flightless I (Drosophila) homolog antibody
      • Flightless I homolog antibody
      • Flightless I homolog (Drosophila) antibody
      • Flightless1 antibody
      • FlightlessI antibody
      • fliI antibody
      • FLII_HUMAN antibody
      • Fliih antibody
      • FLIL antibody
      • MGC39265 antibody
      • Protein flightless 1 homolog antibody
      • Protein flightless-1 homolog antibody
      see all

    Anti-Flightless I antibody 画像

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human prostate carcinoma, using 1/100 ab84778 in conjunction with 1/100 Goat anti-Rabbit IgG secondary antibody conjugated to a fluorescent dye (red).
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human breast carcinoma, using 1/250 ab84778 followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human colon carcinoma, using 1/250 ab84778 followed by DAB staining.

    Anti-Flightless I antibody (ab84778) 使用論文

    ab84778 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"