製品の概要

  • 製品名Anti-FLASH antibody
    FLASH 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FLASH
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region between residues 1650 and 1700 of human FLASH (NP_036247.1)

  • ポジティブ・コントロール
    • Human controls: Breast Carcinoma, Ovarian Carcinoma, Prostate Carcinoma, Small Cell Lung Cancer tissues. Mouse controls: Colon Carcinoma, CT26, Teratoma tissues.
  • 特記事項Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG. Centrifuge microtube to remove product from lid.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab84748 was affinity purified using an epitope specific to FLASH immobilized on solid support.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab84748 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Cytoplasm. Nucleus. Localizes to discrete nuclear foci.
    • Information by UniProt
    • 参照データベース
    • 別名
      • AA387232 antibody
      • C8AP2_HUMAN antibody
      • CASP 8 associated protein 2 antibody
      • CASP8 associated protein 2 antibody
      • CASP8-associated protein 2 antibody
      • CASP8AP2 antibody
      • Caspase 8 associated protein 2 antibody
      • CED 4 antibody
      • CED4 antibody
      • D4Ertd659e antibody
      • FLASH homolog antibody
      • FLASH homolog RIP 25 antibody
      • FLASH homolog RIP25 antibody
      • FLICE associated huge antibody
      • FLICE associated huge protein antibody
      • FLICE-associated huge protein antibody
      • FLJ11208 antibody
      • KIAA1315 antibody
      • mKIAA1315 antibody
      • OTTMUSP00000005125 antibody
      • RIP 25 antibody
      • RIP25 antibody
      • RP23-69G24.1 antibody
      see all

    Anti-FLASH antibody 画像

    • ab84748 at 1/250 dilution staining FLASH in human prostate nodular hypertrophy by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.
    • ab84748 at 1/250 dilution staining FLASH in mouse teratoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    Anti-FLASH antibody (ab84748) 使用論文

    ab84748 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab84748.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"