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RabMAb

Anti-FLAP 抗体 [EPR5640] (ab124714)

製品の概要

  • 製品名
    Anti-FLAP antibody [EPR5640]
    FLAP 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR5640] to FLAP
  • アプリケーション
    適用あり: WBmore details
    適用なし: Flow Cyt,ICC/IF,IHC-P or IP
  • 種交差性
    交差種: Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human FLAP

  • ポジティブ・コントロール
    • Raji, THP-1, HepG2, and K562 cell lysates
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab124714 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 18 kDa.
  • 追加情報
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • ターゲット情報

    • 機能
      Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
    • 関連疾患
      Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
      Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition.
    • 配列類似性
      Belongs to the MAPEG family.
    • ドメイン
      The C-terminal part after residue 140 is mostly unstructured.
    • 細胞内局在
      Nucleus membrane. Endoplasmic reticulum membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 5-lipoxygenase activating protein antibody
      • AL5AP_HUMAN antibody
      • ALOX 5AP antibody
      • ALOX5 AP antibody
      • ALOX5AP antibody
      • Arachidonate 5 lipoxygenase activating protein antibody
      • Arachidonate 5-lipoxygenase-activating protein antibody
      • Five lipoxygenase activating protein antibody
      • FLAP antibody
      • MK 886 binding protein antibody
      • MK-886-binding protein antibody
      see all

    画像

    • All lanes : Anti-FLAP antibody [EPR5640] (ab124714) at 1/1000 dilution

      Lane 1 : Raji cell lysates
      Lane 2 : THP1 cell lysates
      Lane 3 : HepG2 cell lysates
      Lane 4 : K562 cell lysates

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 18 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    プロトコール

    参考文献

    ab124714 has not yet been referenced specifically in any publications.

    レビューと Q&A

    There are currently no Customer reviews or Questions for ab124714.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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